The agouti locus in mice has three alleles: a is recessive and confers a black c

Question

The agouti locus in mice has three alleles: a is recessive and confers a black coat, A is dominant to a and confers an agouti coat, and AY is dominant to both and confers a yellow coat. AY is also a recessive lethal. In addition, the independently assorting c allele is recessive (to C) and prevents the mice from making any fur pigments at all, whether yellow, agouti or black. Two mice are crossed, and produce offspring in a ratio of 1 albino : 2 yellow : 1 black. What are the genotypes and phenotypes of the parent mice?

Explanation / Answer

The agouti locus in mice has three alleles:

a is recessive and confers a black coat,

A is dominant to a and confers an agouti coat, and

AY is dominant to both and confers a yellow coat.

AY is also a recessive lethal.

In addition, the independently assorting c allele is recessive (to C) and prevents the mice from making any fur pigments at all, whether yellow, agouti or black.

Two mice are crossed, and produce offspring in a ratio of

3 albino :cc

2 yellow :AY

1 black.-aa

What are the genotypes and phenotypes of the parent mice?

Cc AY -------- yellow coat.

Cc   A -----agouti coat,

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