Which of the following statements about protein folding and structure are true?
ID: 181014 • Letter: W
Question
Which of the following statements about protein folding and structure are true?
Misfolded proteins often aggregate in large structures in the cell.
The native structure of a protein is entirely encoded in its amino acid sequence.
Chaperones “know” how to actively fold proteins into their proper final structure.
Misfolded proteins are thermodynamically stable versions of a protein.
Each protein has its own “assigned” chaperone to assist in its proper folding.
Chaperones, like the GroEL-ES complex, work by providing a sequestered environment in which proteins can safely explore the conformational space towards productive folding.
Explanation / Answer
Correct statements are
1: Misfolded proteins often aggregate in large structures in the cell.
2: The native structure of a protein is entirely encoded in its amino acid sequence.
3" Chaperones “know” how to actively fold proteins into their proper final structure.
4: Chaperones, like the GroEL-ES complex, work by providing a sequestered environment in which proteins can safely explore the conformational space towards productive folding.
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