5. Lys residues in the core nucleosome N-terminal tail region makes binding to D

Question

5. Lys residues in the core nucleosome N-terminal tail region makes binding to DNA tighter because the charge on a Lys residue is opposite that on the phosphodiester backbone of DNA. Adding an acetyl group to a Lys residue in the nucleosome makes the nucleosome bind to DNA less tightly because it removes the positive charge on Lys. Which modification of the nucleosome would also have the same effect (i.e., weaken nucleosome binding to DNA by neutralizing some of the positive charges on the nucleosome tails)?



a. Add a single methyl group to lysine.

b. Add two methyl groups to lysine.

c. Add a phosphate to serine.

d. Remove an acetyl group from lysine.

e. (A) and (B).

Explanation / Answer

d. Remove an acetyl group from lysine.

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