You have been cut! While you wage war in the streets of Gotham for your life, yo

Question

You have been cut! While you wage war in the streets of Gotham for your life, your cells wage war against incoming invaders. Place the following statement concerning the fates of unwanted invaders/immigrants in your body in order: The invader is cut apart while alive and digested in the harsh environment of your new super-max detention/recycling center. Die invader, Die! Contact with one of your cells triggers phagocytosis and a signal trough transmembrane proteins triggers the cytoskeleton The vesicle containing the bacterium is pinched off A bacterium that has stormed the outter walls of your body (the skin through the cut) is recognized and tagged as foreign Other vesicles containing hydrolases, enzmes that depolymerize proteins, carbohydrates, lipids, and nucleic acids, as well as other proteins that act to increase the pH of the larger vesicle that contains the invader arrive on the cell's microtubule transportation system and fuse. Kinesin walks its vesicle down the microtubule highways into the cytoplasm. Actin polymerizes to form rods that push out the membrane to form fingers or pseudopods that begin to envelop the bacterium The vesicle containing the bacterium is moved by kinesin

Explanation / Answer

The correct order is the next:

1.- a bacterium that has stormed the outer walls of your body (the skin thorough the cut) is recognized and tagged as a foreign. This step is somewhat obvious, since you can not generate an immune response to what has not been exposed (or to what has not invaded you). The phagocytic cell can not eat something that is not there.

2.- Contact with one of your cells triggers phagocytosis and a signal through transmembrane proteins triggers the cytoskeleton. The bacteria was recognized by receptors (receptors mediators of pyocytosis, to mention a few there are PRR [pattern recognition receptors] SR [Scavenger receptors], receptors for mannose, receptors for opsinins and many more) to activate a cascade of cellular signals and do phagocytosis itself (which covers the emission of pseudopods)

3.- Actin polymerizes to form rods that push out the membrane to form fingers or pseudopods that begin to envelop the bacterium. In the previous step I explained how it came to here, once the microorganism is encompassed by the pseudopods is already inside the cell, contained in structures known as phagocytic vacuoles or phagosomes

4.- The vesicle containing the bacterium is moved by kinesin. Consider that the bacteria is still at the "edge" of the cell, the other vesicles and endosomes with different hydrolytic enzymes are more inside the cell.

5.- Kinesin walks it vesicle down the microtubule highways into the cytoplasm. The vesicle with the bacteria and the other vesicles, endosomes and cytoplasmic lysosomes with the aim of forming a phagosome-lysosome (phagolysosomal fusion)

6.- Other vesicles containing hydrolases, enzimes that depolymerize proteins, carbohydrates, lipids and nucleic acids, as well as other proteins that act to increas the pH of the larger vesicle that contains the invader arrive on the cells microtubule tranportation system and fuse. In the previous step I explained how it came to here, Additionally I can tell you that within the phagolysosome the bacteria are exposed to the damaging effect of the hydrolytic enzymes and the oxygen metabolites (reactive oxygen species [ROI] are generated).

7.- The invader is cut appart while alive and digested in the trash enviroment of you new super-max detention/recycling center. Die invader, Die. The microorganisms die by the toxic effect of the metabolites of oxygen, but their digestion is the result of the activity of lysosomal hydrolytic enzymes. These hydrolases degrade the bacterial components to fragments of variable size (lipids, oligosaccharide, peptides, oligonucleotides and their monomeric units [amino acids, saccharides and nucleotides]) which are reused by the cell at their own benefit.

8.-The vesicle containing the bacterium is pinched off. and finally the components that can not be used are discarded by exocytosis.

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