a transmembrane protein has 1000 amino acids a transmembrane protein has 1000 am
ID: 184975 • Letter: A
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a transmembrane protein has 1000 amino acids a transmembrane protein has 1000 amino acids a transmembrane protein has 1000 amino acids a transmembrane protein has 1000 amino acids 4. Brachyury Structure of X laevis Brachyury protein[D8 TXERI The crystal structure of a T-domain from X laevis bound to DNA. The residues highlighted in red are the Ser128, with green residues representing residues in the partner protein. Blue dashed lines show residue contacts the contact (This work was Batenan Genome Biolegy 2008 99 doi to 1186/b- 2008-9-1-r9) A. Brachybury protein is a dimer. What does that mean? What does this tell you about this B. The figure legend above describes a serine (Ser 128) interacting with the green amino acids which is a threonine. What type of interaction or bond can form between serine and threonine? C. If the threonine was mutated to a valine, would it be able to interact with serine? Explain your answer D. Describe and mark any secondary structures identified on the Brachyury image. E. Brachyury is a DNA binding protein. In the image above, DNA is shown in orange and yellow However, the serine and threonine that we have been examining do not contact DNA. Does that mean that these amino acids are not important for protein function? Could they have another important function?Explanation / Answer
On the whole, all over a given protein family quaternary structure is less conserved as compared to tertiary structure, i.e. while the fold of a polypeptide chain remains structurally analogous the quantity of subunits forming the biologically related quaternary structure can vary considerably, but, if a definite interaction among two protein chains plays a structural or useful role, it is logical to expect that residues at the matching interface are less free to differ therefore increasing evolutionary conservation in these region
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