The serum protein electrophoresis (SPEP) is a simple procedure to analyze serum

Question

The serum protein electrophoresis (SPEP) is a simple procedure to analyze serum proteins, which provides a diagnostic marker for patients with multiple myeloma (MM). For the two panels on the right, 1) which pattern is more likely derived from MM patients? 2) what type of cells are responsible for making the proteins shown in Peak 1 and Peak 2? 3) In comparing IgG present in Peak 1 and Peak 2, which one has high diversity and why? 4) What mechanisms contribute to such high diversity (please list all and explain)?

Explanation / Answer

1. Peak 1 is derived from the multiple myeloma patient. In multiple myeloma there are two sharp spikes one of the heavy chain and one of light kappa or lambda chain.

2. A single clone of Plasma cells produce homogenous monoclonal immunogobulins (M proteins).

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