1. fou are an undergraduate student that works on earthworms. You have identifie

Question

1. fou are an undergraduate student that works on earthworms. You have identified a chemical that you call HOOKBACTIN (HBN for short) that causes wild type earthworms to form hooked worms (See Figure below). Wild type Earthworms No HBN Straight) Addition of HBN (Hooked) You are presently taking BIO260 and decide you are going to use mutational analysis to understand how HBN works. To do this you mutagenize wild type earthworms so that you can look for mutants that may identify genes that are responsible for the effects of HBN on earthworm growth. Suggests at least two mutant screens you could perform to identify mutants that may be useful in your analysis. Hint: remember that mutants with opposite phenotypes are useful for genetic a. analysis. (4 marks) b. Assume your screens are successful explain what you could do next to further an understand the relationship of these mutants to each other. (1 marks)

Explanation / Answer

1. a) To identify the mutants following genetic screens will be used:

b) To understand the realtionship between mutants and the additional genes involved an enhancer screen is used. It involves a mutant individual that has an affected process of interest with a known gene mutation. The screen is then performed to identify additional genes or gene mutations that have an impact on that biological or physiological process. The genetic enhancer screen identifies the mutations which enhance a phenotype of interest in an already mutant organism.

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