Part D Henry has a close relative who carries the gene for sickle cell anemia. I

Question

Part D Henry has a close relative who carries the gene for sickle cell anemia. In this genetic disease, the 6th amino acid in hemoglobin (the protein in red blood cells that is responsible for carrying oxygen) is changed from glutamate (Glu) to valine (Val). If the nucleotides in DNA coding for these 6 amino acids were numbered, which nucleotide is most likely to be involved in this mutation? View Available Hint(s) the 18th nucleotide the 17th nucleotide O the 1st nucleotide O the 6th nucleotide Submit Part E Henry is considered a poor metabolizer (PM) because the

Explanation / Answer

Choice 1 is correct

Reason: It is very well known that each amino acid is encoded by a triplet of nucleotide codons. According to the information, the 6th amino acid has been altered in this individual and hence, 6*3 or 18th codon must have undergone mutation.

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