9 of 9 Part E Henry is considered a poor metabolizer (PM) because the changes fo

Question

9 of 9 Part E Henry is considered a poor metabolizer (PM) because the changes found on both of his CYP2C9 genes means that the enzymes responsible for breaking down warfarin were not functioning properly. Which of the following could explain how someone could be an extensive metabolizer (EM) while also having nucleotide changes on both of these genes? View Available Hint(s) The nucleotide changes did not lead to a change the enzyme was unaffected The amino acid substitutions that resulted from the overall shape of the enzyme, so the enzyme O in the amino acid that was being coded for, so the change in the DNA did not have an effect on was unaffected The nucleotide changes caused changes in the amino acids being coded for, but the amino O acids being substituted were very similar to the original amino acids, so the enzyme was unaffected O All answers listed are possible

Explanation / Answer

Answer: Choice 4 is correct

Reason: A change in amino acid is possible only when a mutational change takes place which leads to change in coding sequence and hence, the type of amino acid it synthesizes. Any silent mutation or substitution mutation does not lead to change in sequence or type of amino acid and hence no net change takes place. This is because many codon sequences encode for a single amino acid and many amino acids are encoded by more than one type of codon.

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