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If the cystic fibrosis allele protects against tuberculosis the same way the sic

ID: 186575 • Letter: I

Question

If the cystic fibrosis allele protects against tuberculosis the same way the sickle-cell allele protects against malaria, then which of the following should be true of a comparison between regions with and without tuberculosis?

A. Cystic fibrosis deaths should be more common in regions with tuberculosis.

B. Cystic fibrosis deaths should be less common in regions with tuberculosis.

C. Cystic fibrosis deaths should be equally common in both types of regions.

D. Regional differences in the cystic fibrosis death rate should be purely random and unpredictable.

Explanation / Answer

The correct option is A. Cystic fibrosis deaths should be more common in the regions with tuberculosis.

Cystic fibrosis is a genetic disorder that affects mostly the lungs. Long-term issues include difficulty in breathing and coughing up mucus from lung infections. In a region where tuberculosis is present, cyctic fibrosis death will increase.

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