Name: Pathophysiology Discussion I: Nervous System (Spring 2018) R.O., a 19 year

Question

Name: Pathophysiology Discussion I: Nervous System (Spring 2018) R.O., a 19 year old female, is admittod to the ER by her roommates who said they observed several months of altered behavior. She has become increasingly paranoid that people were spying on her, and she is unable to articulate herself or think clearly. They describe an incidence that occurred carlier that day when R.O. claimed she was raped by the cab driver and reacted violently. She is admitted to the emergency room where she reports that the she was raped and beaten by the police. She denies any visual or auditory hallucinations. However, she claims to have lost interest in her daily activities and an inability to feel pleasure. 1) What is the most likely diagnosis for R.O.? Activity 1: Determine the dopamine levels in each dopamine tract in schizophrenia patients without treatment schizophrenia patients with 1" generation antipsychotic treatment and 2" generation antipsychotic treatment, compared to non-schizophrenia patients. Also, determine the dopamine tract that is involved in positive vs. negative symptoms of schizophrenia, determine the effect of I "generation vs.2" generation antipsychotic treatment on positive and negative symptoms, and possible adverse effects. DA levels in schiophrenia pt without Name of Dopaminras ment;awodiated mtomsodated smgtoms generation antipsydhotic effect on generation antipaydhotic effect on advere effets amodted symptoms aderse effects The clinician decides to treat R.O. with Haloperidol. 2) Is this a 1" or 2" generation antipsychotic? What will be the effectis) of Haloperidol on R.O.'s positive and negative symptoms? Explain 3) Name one adverse effecet associated with the use of Haloperidol. Explain the mechanism. Due to the adverse effects of Haloperidol, the clinician decides to change R.O.'s medication to Risperidone 4) Will the effectis) of Risperidone be different than Haloperidol, regarding R.O.s positive and negative symptoms? How will they be different? Why will they be different?

Explanation / Answer

2. Haloperidol is a first generation antipsychotics

3.

4

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