QUESTION 10 You are an animal composed of segments, like an earthworm, wasp, or

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QUESTION 10 You are an animal composed of segments, like an earthworm, wasp, or centipede. Your segments are not visible until you remove your skin and look at the muscles of your torso as well as your vertebrae and ribs. Your muscles develop in blocks called somites from your head(anterior) to your tailbone(posterior). Protein signals from the head interact with receptors in cells further down to control the number and size of your somites. One of these signals is delta it binds the receptor Notch. When Delta folds its fold contains units of secondary structure that are repeated, each unit folding on its own. These repeats are called EGF-like repeats. In the final fold these units stack together to make a solenoid shape (a hollow spiraled tube somewhat like a short or partial helix) Which of the following terms are appropriate to describe a single EGF repeat in the chain? Pick ALL that apply tertiary structure secondary structure C domairn D. a structure found at the bottom of a protein folding funnel E. a structure found at the top of a protein folding funnel F. a structure found in the center of a protein folding funnel G. super secondary structure [ ] H. quarternary structure

Explanation / Answer

10. In general EGF repeats are known as domain that conserved in EGF like domain containing proteins. It is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet. Beta sheet is a common motif present in regular secondary structure of proteins.

11. May also be involved in protein-protein interactions, and other options mentioned in c.

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