Which of the following sequences of enzymatic activity would produce one of the
ID: 186973 • Letter: W
Question
Which of the following sequences of enzymatic activity would produce one of the nucleotides that is used as a substrate by a polymerase? Choose one: O A. A nucleoside diphosphate kinase reaction, then a ribonucleotide reductase reaction, and finally a guanylate O B. A guanylate kinase reaction, then a ribonucleotide reductase reaction, and finally a nucleoside diphosphate OC. An adenylate kinase reaction, then a guanylate kinase reaction, and finally a ribonucleotide reductase kinase reaction. kinase reaction. reaction. D. Aribonucleotide reductase reaction, then an adenylate kinase reaction, and finally a nucleoside diphosphate kinase reaction.Explanation / Answer
Answer:
Option B is correct.
Explanation:
Sequence of reactions:
NMP ------> NDP ------> dNDP ------> dNTP ------> DNA synthesis
The reaction catalyzed by Guanylate kinase:
It is a nucleoside monophosphate kinase
GMP + ATP ------> GDP + ADP
The reaction catalyzed by Adenylate kinase:
It is a nucleoside monophosphate kinase
AMP + ATP ------> 2ADP
Nucleoside monophosphate kinases do not exhibit specificity for sugar (ribose or deoxyribose)
The reaction catalyzed by Ribonucleotide reductase:
NDP ------> dNDP
Reaction catalyzed by Nucleoside diphosphate kinase:
dN1TP + dN2DP ------> dN2TP + dN1DP
N1TP + N2DP ------> N2TP + N1DP
They exhibit no specificity for the base or sugar
Related Questions
drjack9650@gmail.com
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.