Chapter 12 Open-Angle Glaucoma (OMIM 137750, 602432) ts fluid from out of In ope

Question

Chapter 12 Open-Angle Glaucoma (OMIM 137750, 602432) ts fluid from out of In open-angle glaucoma, cell death in the optic nerve the eye. The pressure from the constrained fluid impairing peripheral vision. Surgery, laser treatment, or drugs can relieve the pressure. Vision is usually not noticeably affected until after age 40. Several mutations in a gene on chromosome 1, GLC1A·cause this condition. However, some polymorphisms in the gene do not affect the phenotype. up in the eyeball, eventually WORKSHEET 1. Three mutations in the GLC1A gene that cause open-angle glaucoma are indicated below. Write codon changes that could account for these changes in amino acid sequence: a. b. c. tryptophan to arginine glycine to valine tyrosine to histidine 2. The following polymorphisms in the GLCIA gene do not alter the amino acid sequences. Write possible codon changes for a. b. proline to proline threonine to threonine c. glutamate to glutamate 3. How can a change in a gene's sequence not alter the protein product? 4. A gene that, when mutant, can cause open-angle glaucoma might encode a protein that participates in: b. apoptosis. c. meiosis. d. DNA replication. 39

Explanation / Answer

a)Chromosome segregation

Glaucoma is a common complex heterogenous disease and it cause the irreversible blindness worldwide.it is define as a group of complex disorder character retinal ganglion visuals field defects,which reflect optic nerve atrophy ,

primary open angle glaucoma occurs in absence of identificable secondary cause,POAG is mostly based on the age of onset and therefore its classified Primary cogenital glaucoma and juvenile open angle glaucomaand adult onset POAG 35-40 year,

^^^^Most common type of Glaucoma nerve connecting the eye to the brain is damaged,usually high eye ball pressure,

slow vision loss,angle closure glaucoma,and medical emergence,symptom eye pain with nausea,

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