6. The lateral diffusion of a plasma membrane protein has been studied using the

Question

6. The lateral diffusion of a plasma membrane protein has been studied using the fluorescence recovery after photobleaching (FRAP) technique in a cell under normal conditions, and the following plot has been obtained. Under a different condition (e.g. when a signaling pathway is turned on), the protein binds to a few other proteins and protein complexes in the plasma membrane. As a result, its lateral diffusion coefficient is reduced and a significant fraction of the molecules of this protein are immobilized in large aggregates. How would you expect the FRAP curve to change under these new conditions? The dotted line in each graph is the original curve shown for comparison. 100 Time (s)

Explanation / Answer

in my opinion option first is correct because in this option at the time of decrease of FRAP all curve shows same reactions due to photo bleaching.

after the recovery by photobleaching the proteins are bounded with other protein that is why no fluorescence and then after protein binding decreases and we will get the curve.

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