binding site and term te and termenes ne converting the Many isses affc the pssi
ID: 187753 • Letter: B
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binding site and term te and termenes ne converting the Many isses affc the pssion sm the l hecause organisms orrespondin8 tRNA-diner roteins levv. of cid the level codons that are rare in the ssue The wne the gene of interest can resolve thh make the protein more stable C e or expressing a molecular combinant protein is produced ressi on vectors can control n bodies sing regulated ed Another factor is protein exportthe rted outside the cell" is easier whith nt protein is prd if they are expo elase and panit recombinant prot tein modifications, such as glycosylation an wombinant proteins require protein ailable only in eukaryotic cells this sometin ummalian cell culture systems that ate s, and es l eads to the use of yeast, insect c End-of-Chapter Questions omb 1. Which of the following is a clinically relevant protein produced by reo a. insulin b. interferon c. factor VIll d. tissue plasminogen activator e. all of the above 2. Which of the following is associated with translation efficiency for the mRNA of genes cloned for protein expression? a. mRNA stability b. strength of the ribosomal binding site c. codon usage d. mRNA secondary structure e. all of the above 3. Which of the following is not a feature of translational expression vectors? a. a selectable marker (i.e., antibiotic resistance) b. terminator sequences c. the native promoter for the gene that is to be cloned into the vector d. consensus RBS plus the ATG initiation codon e. a strong, but regulated, transcriptional promoterExplanation / Answer
1) all the above.
Tissue plasminogen activator (TPA) Activase by Genentech. human insulin (BHI): Humulin from Lilly . Factor VIII: Kogenate from Bayer replaced blood harvested factor VIII. Interferon (IF) Interferon-beta-1a: Avonex from Biogen Idec.
2) e all of the above.
3) promotor need not to be native. it should be stong and regulated.
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