5) 2 points. Albinism in humans is a relatively rare recessive condition. Let th

Question

5) 2 points. Albinism in humans is a relatively rare recessive condition. Let the allele for normal pigmentation be A and the allele for albinism be a. Therefore, individuals with the genotypes AA and Aa are normally pigmented individuals and aa are albinos. Suppose that in the US the frequency of albinos is 1 in 10,000. Estimate the allele frequencies and the frequencies of AA, Aa and aa genotypes in the population. Show all your work, and clearly state your logic and any assumptions you make in estimating the frequencies

Explanation / Answer

Dominant = WT allele = A

Genotype = AA or aa

Recessive = Albinism allele

Genotype = aa

Total population = 10000

Frequency of albinism = aa = 1/10000 = 0.0001

If we assume that the population is in H-W equilibrium,

q^2 = 0.0001

q = 0.01

p = 1 - 0.01 = 0.99

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