(3) There appear to be two populations of monocytes (CD2+ Mo and CD2- Mo). CD2 i

Question

(3) There appear to be two populations of monocytes (CD2+ Mo and CD2- Mo). CD2 is an immune cell marker that may indicate differentiation into dendritic cells (DC). Briefly explain how this suggests (supports) the hypothesis that monocytes circulating in the blood can differentiate into DC (to "MDC1" populations of DC bylines in the Myeloid immunophenotyping diagram, above), rather than only bone marrow progenitors differentiating into DC. What other marker(s) might you look for on CD2+ Mo in the PBMC that would further distinguish them as DC precursors?

Explanation / Answer

This is due to that the monocytes present in the blood contains the CD2+ marker expression on the cell surface. The CD2+ has a major role in differentiating monocyte into dentric cells. CD2- cells not able to differentiate has dentric cells. It does not have that role.

Monocytes had differentiated into DCs, as assessed by the up-regulation of CD11c. So we need to see this marker also.

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