Gene Expression and the Impact of a Mutation I. Using the DNA coding strand sequ
ID: 190483 • Letter: G
Question
Gene Expression and the Impact of a Mutation I. Using the DNA coding strand sequence provided in the 5' 3, direction, predict the sequences of the DNA template strand in the 3' 5' direction, the mRNA 5' 3', and polypeptide for this section of wild-type -globin (one of the polypeptides in hemoglobin) DNA coding strand for wild-type -globin On the line above, write the sequence for the DNA template strand, and label the ends. mRNA for wild-type -globin: Polypeptide for wild-type hemoglobin: coo 2. Now consider the sequence that results in sickle-cell -globin. Using the DNA coding strand sequence provided, predict the sequences of the DNA template strand, mRNA, tRNA anticodons, and polypeptide for this section of the sickle-cell -globin gene. DNA coding strand for sickle-cell -globin: S'ACTGCCCIATGIGTGICACICTGIACTICCTIGTGIGAGI On the line above, write the sequence for the template DNA strand. mRNA for sickle-cell -globin: Freeman Ready-to-Go Teaching Module copyright O 2017 Pearson Education, Inc.Explanation / Answer
1. THE ANSWER IS
5'ACTGCCC ATG GTG CAC CTG ACT CCT GAG GAG3'
3'TGACGGG TAC CAC GTG GAC TGA GGA CTC CTC5'
5'ACUGCCC AUG GUG CAC CUG ACU CCU GAG GAG3'
1 ATG GTG CAC CTG ACT CCT GAG GAG 24
1 Met Val His Leu Thr Pro Glu Glu 8
2. THE ANSWER IS
5'ACTGCCC ATG GTG CAC CTG ACT CCT GTG GAG3'
3'TGACGGG TAC CAC GTG GAC TGA GGA CAC CTC5'
5'ACUGCCC AUG GUG CAC CUG ACU CCU GUG GAG3'
1 ATG GTG CAC CTG ACT CCT GTG GAG 24
1 Met Val His Leu Thr Pro Val Glu 8
3. THE ANSWER IS
TGACGGG TAC CAC GTG GAC TGA GGA CTC CTC
TGACGGG TAC CAC GTG GAC TGA GGA CAC CTC
ONE NUCLEOTIDE HAS CHANGED I.S T TO A. ONE CODON HAS CHANGED. GLU MUTATED WITH VAL.
4. One amino acid coded for another, it is reffered as missense mutation, and this type of mutation is reffered as point muation.
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