Amyloid precursor protein (APP) can be cleaved in the brain to produce amyloid-

Question

Amyloid precursor protein (APP) can be cleaved in the brain to produce amyloid- (AB) peptides. I he accumulation of A3 peptides is associated with neuronal damage and Alzheimer's disease A. Briefly explain why A peptides are damaging in the brain. B. Aducanumab is an antibody therapeutic showing promise in clinical trials for clearing A from the brains of Alzheimer's patients. Aducanumab binds A with a KD of 7.6 nM at physiological temperature (37 °C), and the immune system then recognizes the antibody-AB complexes for removal. What is the Gibbs free energy change for the association of the antibody with A? C. To improve the stability of aducanumab, a glycine residue located in a -strand is mutated to alanine. Draw energy diagrams for the folding energies of wildtype antibody versus the GA mutant. Indicate the G for folding

Explanation / Answer

Answer a:- Amyloid beta is a proteolytic product of Amyloid precursor protein and it is known to cause neuropathological disorder which leads to abnormal metabolism of Amyloid precursor protein. It is known that beta Amyloid peptide is found in Amyloid plaques which destroy the brain region results in various neurological disorder such as Alzheimer disease, down syndrome and so on. Defects in the Amyloid precursor protein results in cerebral hemisphere.

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