Question 2.5) Mycobacteria are intracellular pathogens that have adapted to life

Question

Question 2.5) Mycobacteria are intracellular pathogens that have adapted to life inside phagocytic cells, such as macrophages. These intracellular bacteria are taken up by phagocytosis, similar to other pathogens, but the bacteria are not killed. One possible mechanism that could account for this immune evasion by mycobacteria is their ability to:

Choose one that apply:

A) Kill the macrophage before it kills them

B) Prevent the expression of antimicrobial peptides in the phagosome

C) Prevent the acidification of phagosomes

D) Prevent fusion of phagosomes with lysosomes

E) Prevent induction of nitric oxide production in the phagosome

Explanation / Answer

Answer - D

Inside phagosomes M. tuberculosis secretes the phosphatase SapM and the serine/threonine kinase PknG to prevent phagosome-lysosome fusion. The presence of cholesterol at the mycobacterial phagosome is also required for the prevention of phagosome-lysosome fusion

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