25. Your are trying to identify the region of a gene associated with a particula

Question

25. Your are trying to identify the region of a gene associated with a particular cancer. The table below gives LOD score values for different levels of recombination for five markers on Chromosome 17. Which marker is likely to be closest to the putative cancer gene? RF 0.001 11.9 8.2 39.1 0.01 0.05 0.10 0.20 0.30 D17S250 D175579 D175588 NME1 D175574 8.9 1.6 11.4 0.8 31.7 8.6 18.4 6.0 13.3 3.8 12.1 21.3 8.7 2.7 7.3 12.6 20.2 9.1 6.3 6.7 9.2 14.8 6.8 7.5 a) D17S250 b) D17S579 c) D175588 d) NME1 e) D17S574

Explanation / Answer

Answer: ( c) D175588

D175588 has the highest LOD score. High LOD score indicates the likelihood of linkage occuring at this distance is 1000 times greater than no linkage.

Occurence of specific alleles at 2 loci with a frequency greater than expected leads to linkage disequilibrium.

When a disease mutation arises on a founder chromosome -in this case chromosome 17, the disease mutation will be in linkage diseuilibrium.

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