How does an inhibitor of N-acetylglucosamine phosphotransferase affect lysosomal

Question

How does an inhibitor of N-acetylglucosamine phosphotransferase affect lysosomal protein sorting? As a result of the treatment, lysosomal proteins.. (1 point) O are secreted from the cell. O are retained in the Golgi network. are retained in the ER. O remain tightly bound to M6P receptors O accumulate in the lysosome as non-functional precursor proteins. 2. Which of the following modification is most likely to happen on a protein that passes through the cisternae of the Golgi? The protein is...... as you answer this question, please think about where each of these modifications processes take place! 1 point) O modified co-translational with a pre-formed N-glycan "tree" if it contains an Asn - X-Ser/Thr consensus site O folded by BiP O poly-ubiquitinated O interacting with PDI to help it form the correct disulfide bonds modified on its N-glycan in a step-wise fashion through additional and removal of sugars

Explanation / Answer

Answer

1. Secreted from the cell.

If any defective in N-acetylglucose aminophosphotransferase mannose 6 phosphate is not added to the lysosomal proteins. So, the proteins not able to reach the lysosomes it automatically secreted out to the cell by exocytosis.

2. Modified on its N-glycan ina step wise manner through additional and removal of sugar.

All the other options happen in Endoplasmic reticulum.

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