The following pedigree shows the inheritance of Tay Sachs disease, a fully-penet
ID: 192162 • Letter: T
Question
The following pedigree shows the inheritance of Tay Sachs disease, a fully-penetrant homozygous recessive disorder. A molecular marker “M” has been found to be linked to the disease gene. DNA was collected from all the individuals in the pedigree, and used to analyze the molecular marker, a VNTR, which is found in four different forms in the population (M1-M4). The DNA analysis for each individual in the pedigree is shown on the right.
Which form of the molecular marker is linked to the Tay Sachs disease allele in each side of the family?
a) M1 in the father's family (individual E), and M3 in the mother's family (individual F).Explanation / Answer
Answer: (c) M2 in the father's family (individual E) and M2 in the mother's family (individual F)
Tay-sachs disease is caused by genetic mutation on chromosome 15 inherited from apersons parents in an autosomal recessive manner. Both mothe and father are heterozygous for the trait and are not affected.
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