2. (5 pts) Hemostasis (fill in the blank) This pharmaceutical (generic name) inh
ID: 192245 • Letter: 2
Question
2. (5 pts) Hemostasis (fill in the blank) This pharmaceutical (generic name) inhibits platelet plug formation. Clotting factor necessary for promoting fibrin crosslinking Enzyme that activates fibrinogen to fibrin Protein that breaks up fibrin clots after healing has started. First clotting factor that is activated by both intrinsic and extrinsic pathways. Growth factor that stimulates proliferation of new endothelial cells. These two native molecules, released by the endothelium, prevent platelet plug formation... downstream of injury The inactive form of thrombin.Explanation / Answer
Factor XIIIa is a transglutaminase and is the clotting factor necessary for fibrin cross linking. The glutamine residues on one fibrin binds to the lysine residue on another fibrin molecule forming strong isopeptide bonds.
Thrombin is the enzyme that converts the soluble fibrinogen to gel-forming fibrin.
Plasmin is the protein that breaks up fibrin clots after healing has started.
Factor V is the first clotting factor that is activated by both intrinsic and extrinsic pathways. This converts prothrombin to thrombin.
Prothrombin is the inactive form of thrombin.
Vasculoendothelial growth factor is the growth factor that stimulates proliferation of new endothelial cells.
Antiplatelet and anticoagulant are the two native molecules released by the endothelium to prevent platelet plug formation.
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