(5 pts) Answer the following questions about protein structure by entering the a
ID: 192307 • Letter: #
Question
(5 pts) Answer the following questions about protein structure by entering the appropriate word from the list below in each blank. Note that some words will not be used. 12. ligand motif antiparallel heme cofactor denatured globular tertiary fibrous parallel A beta sheet in which alternating segments have opposite N-to C-terminal orientation is a. referred to as b. A protein that has lost its native three-dimensional structure and its function is said to be c. A molecule or ion that binds reversibly to a specific site on a protein is calleda d. A protein that is composed of a single major secondary structure and has an extended e. A folding pattern that is easily recognizable and occurs in multiple proteins is called a conformation is classified as (2 pts) Which of the following is NOT a feature of the "induced-fit" model of protein-ligand interaction? 13. a. Shapes of ligand and binding site are generally complementary but not an exact match. b. Conformational changes can occur in the binding site upon initial contact with its ligand. c. Conformational changes can occur in a ligand as well as in a binding site d. Conformational changes increase the number of noncovalent ligand-binding site contacts. e. A given binding site can interact with only one ligand.Explanation / Answer
12 a) Antiparallel Beta Sheets.
b) Denaturation
c) Ligand Binding Site
d) Beta Pleated sheets
e) three dimensional structure.
13 a) not a feature . In the case of macromolecules (e.g. proteins), induced fit shows the changes in the shape of a macromolecule in response to a ligand binding so that the binding site of macromolecule conforms more efficiently to the shape of the ligand. The enzyme will change its shape until it is completely complementary to a substrate to activate the enzyme-substrate complex.
d) not a feature Since the substrate is directed to the active site of an enzyme, a covalent bond forms between the substrate and the enzyme. Example: Proteolysis by serine protease is a reaction when proteases have a serine active site that forms a covalent bond between the alkoxyl group of serine and carbonyl carbon of the peptide.
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