Where would you find the precursor of a mitochondrial matrix protein in the foll
ID: 192731 • Letter: W
Question
Where would you find the precursor of a mitochondrial matrix protein in the following types of mitochondrial mutants?
A mutation in the Tom22 signal receptor
A mutation in the Tom70 signal receptor
A mutation in the matrix Hsp70
A mutation in the matrix signal peptidase
A mutation in the Tim44 signal receptor
Cytosol
Matrix
Intermembrane space
Outer membrane
-A mutation in the Tom22 signal receptor
-A mutation in the Tom70 signal receptor
-A mutation in the matrix Hsp70
-A mutation in the matrix signal peptidase
-A mutation in the Tim44 signal receptor
A.Cytosol
B.Matrix
C.Intermembrane space
D.Outer membrane
Explanation / Answer
mutation in TOM22 will cause the precursor mitochondrial protein to be in cytosol. because functional TOM22 is a binding site for amino terminal.
Mutation in TOM70 signal receptor- cytosol
mutation in the matrix Hsp70- cytosol.
mutation in signal peptidase- matrix. it will still be attached with the innermembrane by the n-terminus.
mutation in the Tim44 signal receptor- Intermembrane space. because functional Tim44 translocates precursor proteins through inner membrane.
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