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Table 1. Coverage of human transcripts and intergenic regions by alignments with

ID: 193317 • Letter: T

Question

Table 1. Coverage of human transcripts and intergenic regions by alignments with dog and mouse genomic sequence. Nonredundant coverage of human genomic sequence by the best dog and mouse alignments and three-way alignments (COBs) were classified using Ensembl release 11.31.1. Values represent the total length of coverage for each class of sequence and the percentage of each class covered. Sequence class Dog best hits Mouse best hits COBs Mb Mb Mb 5'-UTR 3'-UTR CDS Intron Upstream (5 kb) Downstream (5 kb) Intergenic 3.10 10.60 20.58 192.93 30.29 35.04 360.47 41.9 52.2 60.7 26.0 22.2 25.9 18.3 3.82 10.51 26.00 109.91 22.43 26.27 179.13 51.6 50.9 76.6 14.8 16.4 19.4 1.97 5.66 17.08 46.53 9.33 11.75 77.05 26.6 27.5 50.4 6.8 6.8 8.7 3.9

Explanation / Answer

Hi,

The given table tabulates the comparative analysis of human DNA sequence with that of dog and mouse. The regions of interest such as coding regions (CDS) and other non coding regions are aligned and similarities are given in terms of percentage.

The CDS is the coding part which codes for specific genes and proteins. These regions are conserved to an extent but vary greatly among the species. These are also the regions which give species specific characters. Hence these regions vary significantly.

The non coding regions are pretty much conserved across the species. These regions include upstream cis acting element, promoter sequences, enhancer elements, UTRs..etc. They do not code for protein but play role in gene expression regulation and genome arrangements. Hence we can find similarity in these regions.

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