Which are the followings are true about Vitamin B1? A. Lack of it causes neurolo

Question

Which are the followings are true about Vitamin B1?

A. Lack of it causes neurological diseases

B. Its derivative is involved in the pyruvate to acetyl-CoA reaction

C. Its derivative is involved in the pyruvate to acetaldehyde

D. Its derivative is involved in the alpha-ketoglutarate to succinyl-CoA reaction

multiple answers

A. Lack of it causes neurological diseases

B. Its derivative is involved in the pyruvate to acetyl-CoA reaction

C. Its derivative is involved in the pyruvate to acetaldehyde

D. Its derivative is involved in the alpha-ketoglutarate to succinyl-CoA reaction

Explanation / Answer

Answer - All of the following are true

Vitamin B1 act as coenzyme with TPP. TPP involved in Pyruvate decarboxylase enzyme which convert pyruvate to acetaldehyde. Pyruvate dehydrogenase convert pyruvate to acetyl-CoA where TPP plays important role. Same as in TCA cycle TPP involved in the alpha-ketoglutarate to succinyl-CoA reaction alpha-ketoglutarate dehydrogenase. Also if lack of vitamin B Wernicke-Korsakoff syndrome is a nurological disorder.

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