Suppose an enzyme is subject to feedback inhibition by an endproduct of the path

Question

Suppose an enzyme is subject to feedback inhibition by an endproduct of the pathway involved. Numerous mutants exist that alter the affinity of the enzyme, both higher than normal and lower than normal, for its ordinary substrate. Which of the following would you expect?

Please provide an explanation

None of the mutants are more sensitive to feedback inhibition than normal and none are less so.

Enzymes with higher affinity for substrate are more sensitive to feedback inhibition and those with lower affinity are less sensitive to feedback inhibition.

Enzymes with higher affinity for substrate are less sensitive to feedback inhibition and those with lower affinity are more sensitive to feedback inhibition.

All mutant enzymes would respond differently than normal to feedback inhibition but it's not possible to predict exactly how.

None of the mutants are more sensitive to feedback inhibition than normal and none are less so.

Enzymes with higher affinity for substrate are more sensitive to feedback inhibition and those with lower affinity are less sensitive to feedback inhibition.

Enzymes with higher affinity for substrate are less sensitive to feedback inhibition and those with lower affinity are more sensitive to feedback inhibition.

All mutant enzymes would respond differently than normal to feedback inhibition but it's not possible to predict exactly how.

Explanation / Answer

Enzymes with higher affinity for substrate are less sensitive to feedback inhibition and those with lower affinity are more sensitive to feedback inhibition.

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