15. For a heterozygous individual with genotype Q + Q , what fraction of XYZ com
ID: 194741 • Letter: 1
Question
15. For a heterozygous individual with genotype
Q
+
Q
, what fraction of XYZ complexes would
you expect to be
functional
if the inclusion of one or more mutant proteins results in a non-
functional complex?
(a) 0.03125
(b) 0.06250
(c) 0.5
(d) 0.9375
(e) 0.96875
16. Given the situation which of the following statements would apply,
(a) The
Q
+
allele is likely haplosufficient.
(b) The
Q
+
allele is likely haploinsufficient.
(c) The
Q
allele can unambiguously be considered a gain of function mutant.
(d) (a) and (c).
(e) None of the above.
Explanation / Answer
15. In Q+ allele there is no mutation. So it produces functional protein. But in Q- allele there is mutation which results in non-functional protein. So, While the Q+ allele produces functional protein, Q- allele produces non-functional protein. Hence, the amount of functional protein and non-functional protein are same or in other words 50% of the total protein produced are and functional and the remaining 50% of the total protein produced are non-functional.
Fraction of functional complex = Percentage of functional protein / 100 %
= 50% / 100%
Fraction of functional complex = 0.5
Answer: Option C
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