Random protease digestion of a certain peptide hormone (length=20 amino acyl res
ID: 196235 • Letter: R
Question
Random protease digestion of a certain peptide hormone (length=20 amino acyl residues) revealed the following peptide fragments:
TRP-GLY-LYS-PRO
VAL-GLY-LYS-LYS
SER-MET-GLU-HIS
PRO-ILE
ARG-ARG-PRO-ILE
ARG-TRP-GLY-LYS
PHE-ARG-TRP-GLY
LYS-ARG-ARG-PRO
LYS-LYS-ARG-ARG
PRO-VAL-GLY-LYS
LYS-PRO-VAL-GLY
MET-TYR-SER
MET-TYR
MET-TYR-SER-MET
MET-GLU-HIS-PHE
TRP-GLY-LYS-PRO
among others. What is the likely sequence of the hormone?
TRP-GLY-LYS-PRO
VAL-GLY-LYS-LYS
SER-MET-GLU-HIS
PRO-ILE
ARG-ARG-PRO-ILE
ARG-TRP-GLY-LYS
PHE-ARG-TRP-GLY
LYS-ARG-ARG-PRO
LYS-LYS-ARG-ARG
PRO-VAL-GLY-LYS
LYS-PRO-VAL-GLY
MET-TYR-SER
MET-TYR
MET-TYR-SER-MET
MET-GLU-HIS-PHE
TRP-GLY-LYS-PRO
Explanation / Answer
Considering that the sequence of the peptide fragments in in continuation in the boxes presented above, the mRNA sequence of the hormone can be deduced using the amino acid codon table. Presented here are the sequence for the amino acids (there might be different combinations possible as a singly amino acid has different codons).
TRP-GLY-LYS-PRO- UGGGGUAAACCU
VAL-GLY-LYS-LYS- GUUGGUAAAAAA
SER-MET-GLU-HIS- UCUAUGGAACAU
PRO-ILE- CCUAUU
ARG-ARG-PRO-ILE- AGAAGACCUAUU
ARG-TRP-GLY-LYS- AGAUGGGGUAAA
PHE-ARG-TRP-GLY- UUUAGAUGGGGU
LYS-ARG-ARG-PRO- AAAAGAAGACCU
LYS-LYS-ARG-ARG- AAAAAAAGAAGA
PRO-VAL-GLY-LYS- CCUGUUGGUAAA
LYS-PRO-VAL-GLY- AAACCUGUUGGU
MET-TYR-SER- AUGUAUUCU
MET-TYR- AUGUAU
MET-TYR-SER-MET- AUGUAUUCUAUG
MET-GLU-HIS-PHE- AUGGAACAUUUU
TRP-GLY-LYS-PRO- UGGGGUAAACCU
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