Ques C,D And E 2. The following diagram shows two chromosomes that are engaged i

Question

Ques C,D And E 2. The following diagram shows two chromosomes that are engaged in a double holliday junction structure. The black bars represent base pairs. The red phophodiester backbone repres chromosome and the blue strands represent the paternal copy of the chromosome. Answer the questions below the diagram. ents the DNA strands of the maternal copy of the 1 CT 3' I IALLIT 4 5 A. Denote the 5' and 3' ends of all of the DNA strands in the figure B. What are the identities of the 6 bases marked by question marks at locations 1, 2 and 3 for each chromosome? Denote the correct identities on the figure. C. Mark on the figure the regions of the DNA that is considered heteroduplex DNA if the Holliday junctions were resolved in the locations that they are currently depicted. D. Assume that the Holliday junctions resolve so that there is no crossing over (that is there is no recombination). For the maternal chromosome list all of the possible base identities at the three positions after the cell repairs any mismatches. Do the same for the paternal chromosome. E. Using your answers from part C, determine what all of the possible combinations of base pair sequences at the 6 positions that could be formed after the cell repairs any mismatches.

Explanation / Answer

A) 5'...................3' } maternaL

3'.....................5'} maternal

5'....................3' }paternal

3'.....................5' } paternal

B). At. 1. C ~ G

2. T ~ A. 3. T~A.   

4. A~T. 5. T~A. 6. C~G

C. Both double stranded will change to heteroduplex when resolved

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