Hi there, I am having some trouble with some toxicology questions I was wonderin
ID: 196574 • Letter: H
Question
Hi there, I am having some trouble with some toxicology questions I was wondering if I could get any reassurance on the answers I think they are.
10. The highest concentration of CYP450 enzyme in the liver are found in:
A) Zone 1
B) Zone 2
>C) Zone 3
D) Zone 4
11. The reactive intermediate formed when acetaminophen undergoes Phase I metabolism is:
>A) NAPQI
B) Isoniazid
C) CYP2E1
D) APAP
12. Vinyl chloride causes a rare form of liver tumor called:
A) Cirrhosis
B) Hepatocellular carcinoma
>C) Haemangiosarcoma
D) Centrilobular hepatic necrosis
13. The following enzyme is not measured in the serum as an in vivo indicator of liver damage:
A) ALT
>B) NAPQI
C) AST
D) LDH
14. Which segment of the nephron is the major site of action for nephrotoxicants?
A) glomerulus
B) loop of Henle
>C) proximal tubule
D) collecting duct
15. Damage to podocytes may cause which of the following effects:
A) oliguria
B) acidosis
C) vasoconstriction
>D) proteinuria
E) vasodilation
16. Metallothioneins do NOT bind which of the following:
>A) chloride
B) copper
C) gold
D) mercury
E) cadmium
17. Vasoconstriction of afferent arterioles leads to:
A) increased GFR
B) atherosclerosis
C) proteinuria
>D) decreased GFR
E) polyuria
18. The primary lesion in analgesic nephropathy is:
A) glomerular capillary vasoconstriction
B) increased podocyte filtration slit size
C) brush border apoptosis
>D) papillary necrosis
E) none of the above
19. Chromium damages the proximal convoluted tubule, which results in:
A) increased organic anion secretion
>B) decreased organic anion secretion
>C) decreased glucose reabsorption
D) increased glucose reabsorption
E) increased sodium reabsorption
20. GFR can be measured directly by determining clearance of:
A) insulin
>B) creatinine
C) sodium
D) potassium
E) all of the above
Explanation / Answer
10. The highest concentration of CYP450 enzyme in the liver are found in
Correct option:
C) Zone 3
11. The reactive intermediate formed when acetaminophen undergoes Phase I
Correct option:
A) NAPQI
12. Vinyl chloride causes a rare form of liver tumor called
Correct option:
C) Haemangiosarcoma
13. The following enzyme is not measured in the serum as an in vivo indicator of liver damage:
correct option:
B) NAPQI
14. Which segment of the nephron is the major site of action for nephrotoxicants?
Correct option:
C) proximal tubule
15. Damage to podocytes may cause which of the following effects:
Correct option:
D) proteinuria
16. Metallothioneins do NOT bind which of the following:
Correct option:
A) chloride
17. Vasoconstriction of afferent arterioles leads to:
Correct option:
D) decreased GFR
18. The primary lesion in analgesic nephropathy is:
Correct option:
D) papillary necrosis
19. Chromium damages the proximal convoluted tubule, which results in:
Correct option:
C) decreased glucose reabsorption
20. GFR can be measured directly by determining clearance of
Correct option;
B) creatinine
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