What is the genetic test for a dominant phenotype that says a mutant is a domina

Question

What is the genetic test for a dominant phenotype that says a mutant is a dominant negative?

Question 5 options:

(A/A) phenotype is dominant to (a/A) phenotype.

(A/A) phenotype is different from (a/A) phenotype.

(A/A) phenotype is same as (a/A) phenotype.

(a/A) phenotype is different from (a/a) phenotype.

(a/A) phenotype is same as (a/a) phenotype.

(A/deletion) phenotype is same as (a/A) phenotype.

(A/deletion) phenotype is different from (a/A) phenotype.

(a/deletion) phenotype is same as (a/a) phenotype.

(a/deletion) phenotype is different from (a/a) phenotype.

(A/A) phenotype is different from (a/A) phenotype and (a/A) phenotype is different from (a/a) phenotype.

(A/A) phenotype is dominant to (a/A) phenotype.

(A/A) phenotype is different from (a/A) phenotype.

(A/A) phenotype is same as (a/A) phenotype.

(a/A) phenotype is different from (a/a) phenotype.

(a/A) phenotype is same as (a/a) phenotype.

(A/deletion) phenotype is same as (a/A) phenotype.

(A/deletion) phenotype is different from (a/A) phenotype.

(a/deletion) phenotype is same as (a/a) phenotype.

(a/deletion) phenotype is different from (a/a) phenotype.

(A/A) phenotype is different from (a/A) phenotype and (a/A) phenotype is different from (a/a) phenotype.

Explanation / Answer

Dominant negative is when a gene product mutation adversely affects the normal wild type gene product. It happens when product is able to interact with the same wild type products but some of the functions are blocked.

The answer would be

(A/deletion) phenotype is different from (a/A) phenotype because it causes changes in the function in the mutant due to the deletion. This leads to causing the mutant dominant negative,

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