15. Which of the following reactions represents the ghaconcogenic reversal of PF

Question

15. Which of the following reactions represents the ghaconcogenic reversal of PFK-1 in glycolysis? A fructose-6-P + ADP ® fructose + ATP B. fructose-6-P+H.O&fructose;+P C. fructose. 1.6-bisphosphate + ADP ± fructose 6-P+ ATP D. fructose-1,6-bisphosphate + H,0fructosc-6-P+P E. none of the above 16. The endoplasmic reticulum bound enzyme that hydrolynes glucose-6-phosphate to glucose in liver is B. glacose oxidase. C. hexokinase. is localed in the and produces in vesickes that diffuse to the releasing their contents into the blood stream A. mitochondria; lactate; cytosol B. cytosol; glucose; plasma membrane D, endoplasmic reticulum; glucose, plasma membrane 18. Gluconeogenesis is not simply reversal of glycolysis since 2 pynuvate &glucose; requires of combined ATP and GTP B. 3 C. 4 D. 5 E. 6 19. In the Cori cycle, the liver because it has a typically high- A. shares the load of exercising muscle; acetate level B. converts lactate to lactose; galactose C. shares the load of exercising muscle: N AD NADH ratio D, bums fat ATP E. converts glucose to lactatc: NAD NADH ratio 20. Which of the following is absolutely cssential for the activation of pyruvate carboxylase? A. high concentrations of acetyl-CoA B. low levels of ATP C. high levels of oxaloacetate D. high levels of TCA cycle intermediates E. high levels of citrate 21. Cellular levels of Iructose-2,6-bisphosphate (F-2,6-BP) arc controlled by the tandem enzyme and A. fructokinase, F-2.6-BPase B. F-2,6-BPase: PFK-2 C. PFK-2: PFK-1 D. PFK-1: F-2,6-BPase E. PFK-2: fractokinase

Explanation / Answer

15 correct answer C

phosphofructokinase (PFK) catalyzes the ATP-dependent phosphorylation to convert fructose-6-phosphate into fructose 1,6-bisphosphate and ADP, it is one of the key regulatory and rate limiting steps of glycolysis. PFK is able to regulate glycolysis through allosteric inhibition, and in this way, the cell can increase or decrease the rate of glycolysis in response to the cell's energy requirements. For example, a high ratio of ATP to ADP will inhibit PFK and glycolysis.

16. Correct answer E

Glucose-6-phosphotase

17. Correct answer D

Glucose-6-phosphatase an enzyme found mainly in the liver and the kidneys, plays the important role of providing glucose during starvation. Unlike most phosphatases acting on water-soluble compounds, it is a membrane-bound enzyme, being associated with the endoplasmic reticulum.

18. Correct answer B

3

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