In a second set of experiments, you decide to treat the purified nuclear envelop

Question

In a second set of experiments, you decide to treat the purified nuclear envelope fragments with a solution that disrupts all protein-protein interaction, but that leaves phospholipid bilayers intact. Which of the following proteins would be missing from the nuclear envelope fragments after treatment?

Lamin associated protein 1
Lamin associated protein 2
Lamin-B
Lamin A
The lamin B receptor

You now purify nuclear envelope fragments from cells in which lamin A is mutated. The mutation prevents the recognition of lamin A by its specific protease. You treat the purified nuclear fragments with the same solution used in the previous question. Which of the following proteins would be missing from the nuclear envelope fragments after treatment?

Lamin C
Lamin associated protein 1
Lamin A
B-type lamins
The lamin B receptor

Explanation / Answer

As the lamin B receptor is embedded in the phospholipid bilayer, it couldn't be purified by the treatment.

The bond between Lamin A and Lamin associated proteins could not be broken. So, these two will be missing

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