e virus C has a viral genome of 154,000 bp, and 10,000,000,000 viruses are repli

Question

e virus C has a viral genome of 154,000 bp, and 10,000,000,000 viruses are replicated in an ippos ntected individual in a single day. Assume that a single mutation at a particular location in the virus C genome is needed for virus C to develop antiviral drug resistance to famciclovir. The mutation can bea transition or transversion mutation. If RNA polymerase introduces an error in 1 of every 10,000 bases synthesized, how long will it take for virus C to overcome famciclovir therapy and develop resistance? Round your answer up to a whole number of days. Number 1 day ls

Explanation / Answer

RNA polymerase induces mutation in 1/10000 bases.
So total genome is 154000 bp.
For one replication to complete the virl cycle induces
154000/10000 = 15 mutation happen in 1 virus.

In one day 10,000,000,000 virus particle is replicated
So, 1 virus -------- ------ 15 mutaion
10,000,000,000 virus ----- 666,666,666 mutation in one day.

So in 1 day is enough to produce become famciclovir resistance.

Related Questions

Navigate

• Browse (All)
• Browse E
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.