3. This question concerns the structures of chromosomes. a. The mouse version of
ID: 199125 • Letter: 3
Question
3. This question concerns the structures of chromosomes. a. The mouse version of chromosome 1 is 197 million base pairs in length. How long is the DNA portion of chromosome 1 in meters? b. Based on what we learned in class, how many nucleosomes are found on the mouse version of chromosome 1? Assume that the average length of the linker DNA is 50 bp. c. The haploid human genome is approximately 3 billion base pairs in length. How many histones are predicted to be found within the haploid human genome? Assume that the average length of the linker DNA is 50 bp. d. How many copies of the histone H3 are predicted to be found in the nucleus of a typical human somatic cell?Explanation / Answer
a)
distance between two bp is 3.4 * 10-10 m. for 197 * 106 bp, the length must be their product = 3.4*197 *1010+6 = 669.8 * 10-4 m = 6.698 cm.
b) Nucleosome core wrappings are about 146 bp, on adding linker DNA that holds the cores together we get 196 bp. SO number of nucleosomes would be 197 million /196 = 1.005 million
c) one nucleosome has 8 histone proteins. the haploid human genome has 1000/196 million nucleosomes. Multiplying this with 8, we get 40.816 million histones
d)A diploid human genome will have 81.632 million histones in nucleosomes, one fourth of this will be H3 since there are two H3 in every 8 histones of a nucleosome. so the number of H3 are 20.408 million
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