2.If fumarate levels accumulate due to the reason laid out in the preceding ques

Question

2.If fumarate levels accumulate due to the reason laid out in the preceding question, the reaction catalyzed by which enzyme can be reversed by mass action to eliminate fumarate? What intermediate will then accumulate as the result of this reverse reaction? A. Malate dehydrogenase; malate B. Malate dehydrogenase; oxaloacetate C. -ketoglutarate dehydrogenase; -ketoglutarate D. -ketoglutarate dehydrogenase; succinyl-CoA E. Succinyl-CoA synthetase; succinyl-CoA F. Succinyl-CoA synthetase; succinate G. Succinate dehydrogenase; succinate H. Succinate dehydrogenase; succinyl-CoA

3. If succinate levels accumulate due to the reasons laid out in the preceding questions, the reaction catalyzed by which enzyme will be reversed by mass action to eliminate succinate? What intermediate will then accumulate as the result of this reverse reaction? A. Malate dehydrogenase; malat B. Malate dehydrogenase; oxaloacetate C. -ketoglutarate dehydrogenase; -ketoglutarate D. -ketoglutarate dehydrogenase; succinyl-CoA E. Succinyl-CoA synthetase; succinyl-CoA F. Succinyl-CoA synthetase; succinate G. Succinate dehydrogenase; succinate H. Succinate dehydrogenase; succinyl-CoA

Explanation / Answer

1-option G

2- option E

Note- the reactions are reversible here , where succinyl co a with co a synthase enzyme for succinate which by later dehydrogenase form fumarate , thus this reaction can be reversed when concentration of their product increase.

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