Sickle cell disease is found in numerous populations in the malaria belt of the

Question

Sickle cell disease is found in numerous populations in the malaria belt of the world. It is an autosomal recessive disorder. In a population 4 in 100 newborns have the disease. What is the frequency of the wild type and mutant alleles? What is the frequency of the carriers? Sickle cell disease is found in numerous populations in the malaria belt of the world. It is an autosomal recessive disorder. In a population 4 in 100 newborns have the disease. What is the frequency of the wild type and mutant alleles? What is the frequency of the carriers?

Explanation / Answer

Frequency of affected individual(recessive homozygote) in the population =4 /100.

Recessive homozygote q2= 4/100

Hence frequency of Recessive allele q= 0.2.

Frequency of mutant allele = 0.2.

Frequency of wild allele p=1-0.2 = 0.8.

Frequency of carrier =2pq= 2 x 0.8 x 0.2 =0.32.

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