2). Your friend is interning in a research lab at CERN in Switzerland. The lab t

Question

2). Your friend is interning in a research lab at CERN in Switzerland. The lab they are working in is studying a family of mice named the Quarks. The family consists of parents named Up and Down, monozygotic twins Charm and Strange, and their third child Bottom. In other words, Bottom is Charm and Strange's little brother (and all three mice are the offspring of Up and Down). At the immunoglobulin heavy chain locus Up is homozygous fory3° and Down is heterozygous, having both 3a and Y3"(note: in mice the different alleles are named with letter superscripts) a). Charm has come down with a disease caused by Micrococcus blackholeus and she is unable to launch an effective antibody response against the bacteria. However, the rest of the Quarks have all encountered the pathogen and produced high levels of lgG antibodies against the bacteria. Your friend wants to transfer immunoglobulin to Charm from a family member to confer passive immunity i. Which family member, if any, would be least likely to in induce anti-allotype antibodies in Charm? (1 point) li. Which family member, if any, would be likely to induce anti-isotype antibodies in Charm? (1 point) b). Would injecting serum lgG from Up into Down induce anti-allotypic antibodies? Why or why not? (1 point) c). Bottom suffers from Higgs Syndrome, a condition characterized by extreme weight gain due to the presence of an anti-leptin lgG3 auto-antibody, Should your friend be able to guess which of the other family members will also develop this syndrome (i.e have the same anti-leptin lgG3 antibody)? Explain your reasoning. (1 point) d). Bottom has just discovered his long-lost evil twin Top. Top has a component in his serum called W particles. The W particles appear to be immunolglobulins and have been found to bind to IgG3 antibodies from Down. Using this information determine Top's genotype for y3. (1 point)

Explanation / Answer

I) strange, since both charm and strange are monozygotic twins.

2) isotope is a change in the heavy chain constant region. None of the family members would induce anti-isotope antibodies

3)yes. The allotypes that is the variation in the variable region of an antibody is different in each individual unless they are monozygotic twins and basically have the same genetic make up and hence would induce formation of anti-allotypic effect.

D) down is heterozygous and carries both the alleles a and b, based on this W particles can be a result of aa or bb or ab genotype

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