QUESTION 1 Delta is a peptide hormone and Notch its receptor. Upon binding, the

Question

QUESTION 1 Delta is a peptide hormone and Notch its receptor. Upon binding, the Notch receptor changes shape and the extracellular portion of the receptor is cut off b a protease on the outside of the cell. Upon removal of the extracellular portion of the receptor the transmembrane domain and intercellular portion of the Notch receptor change shape. The intercellular portion is subsequently clipped off on the inside of the cell by a second protease. The Intercellular Domainc Notch (ICD) floats off into the cytoplasm where it interacts with the CSL transcription factor in a complex with other proteins. This entire complex is transported into the nucleus. This signaling system regulates a number of stem cells in the body and affects differentiation of gonads/gametes and breasts among many other things. Pick ALL of the true statements concerning Delt/Notch signaling. Notch signaling turns on genes. Notch signaling has a relatively slow response. Notch signaling involves a kinase cascade. Notch signaling triggers a cytoplasmic enzymatic reaction. Notch signaling involves a membrane receptor. Notch signaling is an example of indirect signaling. Notch signaling is an example of direct signalning. Notch signaling involves a cytoplasmic receptor. Notch signaling involves a second messenger. Notch signaling has a relatively fast response.

Explanation / Answer

Notch signalling turns on genes - HEY1 is a gene that is induced by Notch. Notch signalling has a relatively slow response - Since the notch cascade modifies the gene expression in a cell, the response is relatively slow. Notch signalling triggers a cytoplasmic enzymattic reaction - Notch ligand receptor interaction triggers the cytoplasmic enzyme y-secretase. Notch signalling involves a membrane recepor - Notch signalling involves a notch receptor that is a single-pass transmembrane receptor protein. Notch is an example of direct siganalling - It is an example of juxtacrine signalling that involves a direct contact with cells for signalling.

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