0.45 04 035 03 026 02 0.15 0.1 0.2 03 04 0.5 Figure 2A o.05 15 25 15- What are t
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0.45 04 035 03 026 02 0.15 0.1 0.2 03 04 0.5 Figure 2A o.05 15 25 15- What are the different mechanisms by which cells regulate the activity of enzymes? What is the selective advantage of feedback regulation in cellular metabolism? 16- Discuss the Davson and Danielli model of membrane architecture with regards to: The experimental observations the led to its proposition. Its limitations. a. b. 17- The fluid mosaic model of cells membrane: Indicate which molecular components make up each of the parts (the fluid one and the mosaic one respectively). What is (are) the function(s) of each of this constituents? Which property of membrane lipids is the basis for the bilayer nature of cell membranes? Explain with regard to the environment and the inner composition of living cells. Why is the cell membrane a two-dimensional fluid? What is the importance of membrane fluidity? Discuss the different mechanisms involved in homeoviscous adaptation as it happens in various cell types a. b. c. d. e. f. 18-Discuss the influence of the fatty acid content of phospholipids on membrane fluidity (indicate how it changes with the change in the characteristics of fatty acids).Explanation / Answer
ANSWER 15
Enzymes can be regulated by cell at two level
a) energy charge - it is effective mole fraction of ATP in ATP-ADP-AMP pool.
b) Isozymes - these are different forms of same enzymes having most of the physico chemical properties very similar
c)Zymogen - these are catalytically inactive and large precurssor of an active enztme
d) Feed back control - regulation by which end product inhibit enzyme of committed step
e) hormonal regulation - hormone involves in binding to enzyme receptor on an endocrine cell to regulate hormonal secretion.
2. Quantitative level - it includes synthesis type regulation like transcription, translation and degradation.
Selective advantage of feedback regulation in cellular metabolism : feedback inhibition specially regulates the specific enzyme activity, it ensures that excess of the product should not be produced. for this the excess product itself bind to the aloosteric site of the specific enzyme with slective binding and thus inhibites the enzyme activity. so, because of the selective nature of feedback inhibition it is very important methode for enzyme acitivity regulation.
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