#5: Enzyme Inhibition Consider the production of amino acids in the glutamate fa
ID: 200842 • Letter: #
Question
#5: Enzyme Inhibition
Consider the production of amino acids in the glutamate family, namely, the use of -ketoglutarate to produce the amino acids glutamate, glutamine, proline, and arginine (see Figure 5.8 and 5.13). Consider the situation in which you are tasked with producing the amino acid arginine using a bacterium in which the glutamate family of enzymes is expressed. If the production of these amino acids is subject to sequential feedback inhibition (see figure 4.12), what strategy (addition of specific chemicals to the nutrient broth) would you use to promote the highest level of arginine production?
a) Isozymes b) Concerted Feedback Es c) Sequential Feedback d) Cumulative Feedback 3, E 1 95 Figure 4.12. Examples of feedback control of branched pathways. P, and P, are the de- sired end products. M, M2, . .. M, are intermediates, and E, is the enzyme involved in converting metabolite M, to M, Possible paths of inhibition are shown by dashed lines.Explanation / Answer
the specific chemicals would be proline and proline forms arginine. proline would act as a precursor for arginine production. theother amino acids if added would may or may not form arginine. Addition of proline make it a substrate for production of arginine.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.