You are the project manager of a new start-up company, Miner Miracles, which use

Question

You are the project manager of a new start-up company, Miner Miracles, which uses stem cells to repair or replace pancreatic tissue that has been lost in patients with pancreatic cancer (a debilitating disease with nearly 100% fatality rate due to metastasis and pancreatic failure). If the cancer is caught before metastasizing out of the pancreas, surgeons can remove the pancreas and replace it using a stem-cell generated engineered tissue. Your considerations: 1. What is your stem cell source? Why? What are your concerns about this stem cell? 2. What are 2 benefits of using cell-seeded biomaterial scaffolds for implantation into the defects (as an alternative to injecting a cell suspension or scaffold alone)? 3. What structure and function does your engineered tissue need to satisfy to be functional? How would you test that both in vitro and in vivo? Why would you use those tests specifically? 4. How long would take from harvesting the stem cells to implanting a functional tissue in the body?

Explanation / Answer

The stem cells source is ES cells these are the basic building block of about 260 types of cells in the body,they are used to treat many diseases the concern is that it may pass on viruses or other micro organisms during the transplantation,they need to be directed and cultivated in to specialized cells under great care as it may result in uncontrolled growth which is disastrous

Cell seeded Biomaterial scaffold s for implantation benefits are Biodegradability, biocompatibility and it's properties and structure

Before stem cells are transplanted, they must possess sufficient biological activity to ensure that they will be successful once implanted, often for a person who is extremely ill and can't afford the time-consuming procedure of a stem cell transplant that simply won't work.

Processed membranes are analyzed for expression of alpha gal epitopes,and binding of anti-gal and it's efficiency is tested vitro and vivo

Length of the time depends on the how fluid the stem cells are in ,it also depends on pateint health and other factors.

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