Match the correct (a) target tissue, (b) hormone and (c) major response. 1 point

Question

Match the correct (a) target tissue, (b) hormone and (c) major response. 1 point) 9. Heart, adrenaline, decreased heart rate. Smooth muscle, vasopressin, amylase secretion. O Kidney, parathormone, bone resorption. Ouary, luteinizing hormone, estrogen secretion. Adrenal cortex, adrenocorticotrophic hormone, secretion of cortisol. 10. What can an arrestin do to a GPCR? A. An arrestin can bind to the GPCR and inhibit its signaling. B. An arrestin can stimulate a GRK to phosphorylate the GPCR. C. An arrestin can stimulate endocytosis of the GPCR D. An arrestin can activate MAPK signaling. E. An arrestin can sensitize a GPCR to increase its signaling strength. 1 point) O A only. O A and Bonly. A, C and D only. A, B, C, and D only. A and D only.

Explanation / Answer

9.

Adrenaline secreted by adrenal medulla increases heart rate. The given matching is incorrect.

Vasopressin is produced by posterior pituitary galnd and is involved in water reabsorption. The given matching is incorrect.

Paratharmone is produced by parathyroid glands and reulates calcium levels in blood. The given matching is incorrect.

Luteinizing hormone (LH) is produced by anterior pituitary galnd and stimulates ovulation, development of corpus luteum in females and induces production of progesterone. The given matching is incorrect.

Adrenocorticotropic hormone produced by anterior pituitary stimulates the adrenal cortex to produce cortisol. The given matching is correct. Therefore, option 5 is correct.

10.

Arrestins proteins that regulate the signal transduction at G protein coupled receptors (GPCRs). The deactivation or turning off GPCRs occurs by phosphorylation of serine/ threonine kinases known as G protein coupled receptor kinases (GRKs) resulting in desensitization of GPCRs. Arrestins bind to GRKs and block the signals at GPCRs and later the receptors are internalized by receptor mediated endocytosis or redirect signalling by G protein independent pathways such as -arrestin signaling including mitogen-activated protein kinases (MAPK), ERK and JNK etc. Option 4 is correct.

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