Which of the statements below is/are correct regarding the chemical mechanism of

Question

Which of the statements below is/are correct regarding the chemical mechanism of AdhP, an alcohol dehydrogenase? Select all that apply H2N OH HO CH3 Zn2 u Acetaldehyde is being oxidized The curly arrows are not drawn correctly to convey the now of electrons inte directon of herecciontatis depicted Nicotinamide adenine dinucleotide is being reduced. cetaldehyde is being reduc ai The cuty ar o gotwey the now l electois in che direction of the reaction that is depicted Nicotinamide bdenine dinecleucdeiscei okidized

Explanation / Answer

1.Alcohol dehydrogenases are a group of dehyrogenases enzyme that are found abundantly in many organism and are used as enzymes for reduction and oxidation of carbonyl group with inter conversion of aldehyde, ketones, alcohols with reduction of Nicotinamide adenine dinucleotide ( NAD+ to NADH). Alcohol dehyrogenase is a dimeric zince enzyme, found in the cystolic fraction of the cell.

a. It is correct that acetaldehyde is oxidized to acetic acid majorly in the mitochrondria and some fraction of it is done in the cytosol, as this enzyme catalyses the oxidation of ethanol to acetaldehyde.

b. It is incorrect that the curly arrows are not drwn correctly to convey the flow of electrons in the direction of the reaction as the first it is oxidised with a hydride transfer and then it is rearranged and undergoes reduction.

c. It is correct that Nicotinamide adenine dinucleotide is being reduced in this enzyme catalyzed reaction.

d. It is incorrect that acetaldehyde is reduced.

e. It is incorrect that the curly arrows covey that flow of electrons.

f. Nicotinamide adenine dinucleotide is being oxidized, is incorrect.

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