3. Ethylene glycol (found in antifreeze) is metabolized in several steps, as sho

Question

3. Ethylene glycol (found in antifreeze) is metabolized in several steps, as shown in the figure below. Patients who suffer from ethylene glycol poisoning initially appear to have alcohol poisoning: dizziness, loss of muscle coordination, slurred speech. They later develop severe abdominal pain, seizures and kidney failure. The toxicity of ethylene glycol is due to the production of glycolic acid and oxalic acid during metabolism. The drug Fomepizole is commonly used to treat both ethylene glycol poisoning and methanol poisoning. Based on your knowledge of alcohol metabolism, describe how Fomepizole would be an effective treatment for poisoning by ethylene glycol. Ethylene glycol Alcohol dehydroganase Glycoaldehyde Aldehyde dehydrogenase Glycolic acid Glycine a-hydroxy--ketoadipateGlyoxylic acid- Oxalic acid

Explanation / Answer

how formepizole would be effective for treating ethylene glycol poisoning.

Ethylene glycol and methanol could lead to poisoning that may be life threatening. Formepizole could be used for the treatment of alcohol poisoning since it is an inhibitor of alcohol dehydrogenase. As a result of the inhibition of the metabolism of ethylene or methanol. This acts an antidote of metabolism, as a result of reducing the toxic effects. If it is administered on time, it could prevent renal failure that is caused by ethylene glycol. For example would be interacting with the element of zinc that is present in alcohol dehydrogenase along with the NAD coenzyme, which would prevent it from binding to alcohol.

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