Scenario 1 You examine a new creature\'s Hb called HbX. The creature\'s blood pH

Question

Scenario 1 You examine a new creature's Hb called HbX. The creature's blood pH is the same as ours. Answer the following using the diagram on the last page of this exam (before answer list.) 1.1) The change in position of the N-term amino acid between the deoxy and oxy forms of HbX suggests (a) cooperative binding of O2 (b) the deoxy form has a higher O2 binding affinity than ours (c) the deoxy form has a lower O2 binding affinity than ours (d) non-cooperative binding of O2 (e) 1.2-1.6) HbX's 12 (R or T form is stabilized by the binding of a large molecule whose role is imilar to BPG called BPGx. Starting with the interacting amino acid with the lowest number, give the AA# that would interact with BPGK _13(AA#M#lowerthan lin 1.5L-would form a 1.4 interaction with BPGx 1.5LAA# # higherthan in 1.3L would form a 1.6 interaction with BPGx 1.7) The interaction between BPGx and AAM in 1.3 would be-1.7(strongerorweaken-than the interaction in 1.5. 1.8) Instead of two different AAs listed in 1.3 and 1.5, you find that fetal HbX varies from adult HbX in that it has the same AA in both positions (to clarify, if you chose AA's x and y above, fetal HbX has either x and x or y and y). You expect the same AA as you chose for above to be present in both positions to the affinity for O2 in the fetus. (a) 1.3; increase (b) 1.3: decrease (c) 1.5; increase (d) 1.5, decrease (e)

Explanation / Answer

1.1: D. Non co-operative binding of O2

1.7: weaker than the interaction in 1.5

1.8: D. 1.5; Decreases

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